Category 1 Immunological Problems
HLA Compatibility as a Cause for Recurrent Spontaneous Pregnancy Loss
The HLA antigens on the placenta cells made by the father are called HLA-G. When the couple shares DQ alpha antigens in common, the G molecule put on the placental cells by the father is too similar to the G molecule that the woman's father put on her placenta to sustain her in her mother's uterus.
As a result, she does not make the blocking antibody, the baby dies, and her immune system recognizes the placenta as "altered self" (i.e., a cancer cell) and category 1 problems move on to worsen to categories 2, 3, 4 and 5 (see diagram below).
Consequences
- Inadequate blocking antibody formation.
- Ineffective camouflage of placenta.
- Placental cells fail to grow and divide.
- Death of placental cells.
- Activation of category 2, 3, 4 and 5 immune problems.
HLA-G: Message sent from father to stimulate blocking antibody.
Blocking Antibody: Protects and stimulates the growth of placental cells.
Placental Cell Death: Consequences of low blocking antibody.
Alan E. Beer Center for Reproductive Immunology & Genetics
15151 National Ave. #2; Los Gatos, CA 95032; Phone: (408) 356-9500; Fax: (408) 356-9509; E-mail: info@repro-med.net.
Date: 7-24-08, Time: 9:54 am.
General Question? E-mail: info@repro-med.net.
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