Antibodies to Hormones and Neurotransmitters
Elevated CD 19+5+ Cells
Category 5 Patients
There are five categories of immune problems that can cause miscarriages, infertility, implantation failures and chemical pregnancies. Forty-five percent of women with infertility and implantation failure or IV-ET failures are Category 5 patients. This means that they have elevated CD 56+ cells that produce tumor necrosis factor (a chemotherapy molecule) that either damages the embryo, the trophoblast (placental cell) or the lining of the uterus (decidua) shortly after the start of pregnancy.
Neurotransmitters are serotonin, endorphins and enkaphlins. They function in many parts of our body especially the brain. Serotonin controls the mood and keeps us happy and the endorphins and the enkaphlins are natural opiates and pain relievers in your bodies. They also function in the uterus. By day 13 or 14 of a normal 28 day cycle the endorphins and the enkaphlins help prepare the uterine lining into three zones, five layers and blood flow enters zone three ready to nourish the embryo. Many women with elevated CD 19+5+ cells have antibodies to their own endorphins and enkaphlins and the lining does not develop properly and behaves like Teflon when implantation occurs.
Other women may make antibodies to their own serotonin. Serotonin is necessary to prepare the uterine muscle for pregnancy. Some women make antibodies to their own serotonin and this process is interfered with. On the uterine biophysical profile one can see the uterus on day 13 or 14 contracting three times in two minutes. If this is not occurring then the possibility is high that antibodies to serotonin exist.
There are often symptoms in women who have antibodies to serotonin and neurotransmitters that I have learned about.
- Fibromyalgia: achiness in the small joints and muscles usually in the morning.
- Increasing depression that has no apparent reason.
- Waking early in the morning project oriented and unable to get back to sleep. I meet many of you online at this time. You retreat to your computers and find solace there.
- Sweating at night especially over the chest and the breastbone.
- Increasing PMS symptoms.
- Increasing "bitchiness" for no apparent reasons.
- Panic attacks including a feeling of not being able to handle the work load that before was easy for you.
- Bad uterine lining of less than 8 mm when tested on day 13 or 14.
- Poor stimulation even with mega doses of Fertinex, Pergonal, Gonal F or other drugs.
- Hormone levels that crash in the middle of the cycle.
Yes the list is large! It is a list of complaints that many of you have had. You hear your doctor tell you to relax, take a holiday, cut down your workload, try again. Comments like this really put the problem squarely back on your shoulders and give you more guilt, grief, anger and hopelessness. You do not have to take this. Something is wrong if your score high on the above list!
The information contained in this article is not intended to be a medical diagnosis, treatment or medical advice in any way, as it is general information and cannot be relied on without consultation with your physician. It is not intended nor is it implied to be a substitute for profession medical advice. As medical information can change rapidly, we strongly encourage you to discuss all health matters and concerns with your physician before embarking on new diagnostic or treatment strategies.
Alan E. Beer Center for Reproductive Immunology & Genetics
15151 National Ave. #2; Los Gatos, CA 95032; Phone: (408) 356-9500; Fax: (408) 356-9509; E-mail: info@repro-med.net.
Date: 8-28-08, Time: 3:47 pm.
General Question? E-mail: info@repro-med.net.
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