Testing
Overview of Reproductive Immunology Testing
I. Indicators for Immune Testing:
The indications are as follows:
- Two miscarriages or two IVF failures after age 35 or three miscarriages or IVF failure before age 35,
- Poor egg production from a stimulated cycle (less than 6 eggs),
- Blighted ovum (egg),
- Idiopathic (unknown cause) infertility,
- Previous immune problems (e.g. ANA positive, rheumatoid arthritis, and/or Lupus),
- Previous pregnancies that have shown retarded fetal growth, and
- One living child and repeat miscarriages while attempting to have a second child.
II. Immune Testing
- Antinuclear antibodies (ANA)
- Anti-DNA/Histone antibodies
- Antiphospholipid antibodies (APA)
- Natural Killer (NK) Cell Assay
- Th1/Th2 Assay
- T regulatory cells
- Leukocyte antibody detection
III. Coagulation Testing
- Antiphospholipid antibodies (APA)
- Leiden Factor V R560Q gene mutation
- MTHFR C677T and A1298C gene mutations
- Prothrombin Gene 20210 gene mutation
- PAI-1 4G/5G gene mutation
- Factor XIII V34L gene mutation
- Protein C level
- Protein S level
IV. Metabolic Testing
- Comprehensive metabolic panel
- Fasting glucose and insulin
- Serum serotonin
- Immunoglobulin panel
- Thyroid testing and thyroid antibodies
- Prolactin
Additional Information:
Patients undergoing testing may find our treatment protocol to be helpful. Additionally, they can explore our Patient Resources. Lastly, we recommend numerous Online Resources for general education on reproductive immunology.
We aim to provide a modern and comprehensive understanding of reproductive immunology. Should you have any further inquiries, please feel free to reach out.